Neoplastic and non-neoplastic astrocyte states converge on mesenchymal and injury-response programs during glioblastoma recurrence

Lindgren et al. (Lund University; Cell Reports 2026) profile healthy brain, primary tumors and post-radiotherapy recurrences in a genetically engineered glioblastoma mouse model with single-cell and spatial transcriptomics and immunofluorescence, across 13 non-neoplastic cell types and 10 tumor cell states. They report reactive non-neoplastic astrocytes and tumor cells adopting reactive astrocyte-like phenotypes; reactive astrocyte-like tumor cells with mesenchymal and injury-response signatures are enriched after radiotherapy and persist in recurrences. The authors propose these convergent programs as potential mediators of radioresistance (mouse model; not tested in patients).

Authors / organisation

Lindgren D, Rosberg R, Smolag KI, Johansson E, Braun S, Sjölund J, Manou D, Pracucci E, Phung B, Harbst K, Jeannot P, So YC, Bolivar P, Malmberg M, Ceberg C, Bengzon J, Ahlenius H, Jönsson GB, Pietras K, Pietras A.

Venue

Cell Reports

Date

2026-10-15

Type

paper

Year

2026

DOI

10.1016/j.celrep.2026.118119

PMID

42886556

Verification

PubMed E-utilities PMID 42886556 (title, 20 authors, Lund affiliations, Cell Rep 45(10):118119, epub 2026-10-15, abstract) + Crossref (journal-article, vol 45, article 118119) fetched 2026-10-20; full text not read

GBMRadiotherapyscRNA-seqSpatial omicsPlasticityPreclinical

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