{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"mouse","system":"mouse","evidence_level":"peer_reviewed","importance":"","importance_reason":""},"id":"VC0172","type":"paper","title":"Neoplastic and non-neoplastic astrocyte states converge on mesenchymal and injury-response programs during glioblastoma recurrence","authors_or_org":"Lindgren D, Rosberg R, Smolag KI, Johansson E, Braun S, Sjölund J, Manou D, Pracucci E, Phung B, Harbst K, Jeannot P, So YC, Bolivar P, Malmberg M, Ceberg C, Bengzon J, Ahlenius H, Jönsson GB, Pietras K, Pietras A.","date":"2026-10-15","year":"2026","venue":"Cell Reports","url":"https://doi.org/10.1016/j.celrep.2026.118119","doi":"10.1016/j.celrep.2026.118119","pmid":"42886556","brain_tumor_focus":"yes","tags":["gbm","radiotherapy","scrna-seq","spatial","plasticity","preclinical"],"tag_slugs":["gbm","radiotherapy","scrna-seq","spatial","plasticity","preclinical"],"tag_labels":["GBM","Radiotherapy","scRNA-seq","Spatial omics","Plasticity","Preclinical"],"tag_labels_zh":["胶质母细胞瘤","放射治疗","单细胞 RNA 测序","空间组学","细胞可塑性","临床前"],"unmapped_tags":[],"one_line_summary_en":"Lindgren et al. (Lund University; Cell Reports 2026) profile healthy brain, primary tumors and post-radiotherapy recurrences in a genetically engineered glioblastoma mouse model with single-cell and spatial transcriptomics and immunofluorescence, across 13 non-neoplastic cell types and 10 tumor cell states. They report reactive non-neoplastic astrocytes and tumor cells adopting reactive astrocyte-like phenotypes; reactive astrocyte-like tumor cells with mesenchymal and injury-response signatures are enriched after radiotherapy and persist in recurrences. The authors propose these convergent programs as potential mediators of radioresistance (mouse model; not tested in patients).","one_line_summary_zh":"Lindgren 等（隆德大学；Cell Reports 2026）在基因工程胶质母细胞瘤小鼠模型中，用单细胞与空间转录组及免疫荧光比较健康脑、原发肿瘤和放疗后复发肿瘤，涵盖 13 种非肿瘤细胞类型与 10 种肿瘤细胞状态。研究发现反应性非肿瘤星形胶质细胞，以及呈反应性星形胶质细胞样表型的肿瘤细胞；带间充质与损伤应答特征的此类肿瘤细胞在放疗后富集并持续存在于复发肿瘤中。作者提出这些趋同程序可能介导放疗抵抗（小鼠模型结果，未在患者中检验）。","verified":"yes","verification_source":"PubMed E-utilities PMID 42886556 (title, 20 authors, Lund affiliations, Cell Rep 45(10):118119, epub 2026-10-15, abstract) + Crossref (journal-article, vol 45, article 118119) fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0172/","api_url":"https://gliostate.com/api/items/VC0172.json","sameAs":["https://doi.org/10.1016/j.celrep.2026.118119","https://pubmed.ncbi.nlm.nih.gov/42886556/"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/radiotherapy/","https://gliostate.com/library/tag/scrna-seq/","https://gliostate.com/library/tag/spatial/","https://gliostate.com/library/tag/plasticity/","https://gliostate.com/library/tag/preclinical/"]},"cited_by":[],"related":[{"id":"VC0070","title":"In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.","shared_tags":["gbm","preclinical","radiotherapy"],"page_url":"https://gliostate.com/library/VC0070/","api_url":"https://gliostate.com/api/items/VC0070.json"},{"id":"VC0160","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","shared_tags":["gbm","scrna-seq","spatial","plasticity"],"page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json"},{"id":"VC0140","title":"Divergent genomic evolution in astrocytomas and oligodendrogliomas","shared_tags":["radiotherapy"],"page_url":"https://gliostate.com/library/VC0140/","api_url":"https://gliostate.com/api/items/VC0140.json"},{"id":"VC0134","title":"TumorTwin: a Python framework for patient-specific digital twins in oncology","shared_tags":["radiotherapy"],"page_url":"https://gliostate.com/library/VC0134/","api_url":"https://gliostate.com/api/items/VC0134.json"},{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","shared_tags":["gbm","plasticity","scrna-seq"],"page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0093","title":"Spatial epigenomic niches underlie glioblastoma cell state plasticity","shared_tags":["gbm","spatial","plasticity"],"page_url":"https://gliostate.com/library/VC0093/","api_url":"https://gliostate.com/api/items/VC0093.json"}]}