# GlioState

> GlioState (https://gliostate.com) is a bilingual (English/Chinese), source-verified knowledge hub on AI virtual cells read through a neuro-oncology lens: glioblastoma (GBM) and glioma cell states, other brain tumors, brain metastases and spinal cord tumors. Edited by the GlioState Editorial Team. 139 curated items, each verified against PubMed, Europe PMC, Crossref or an official page. For research and education only; not medical advice.

Chinese versions of every page: append `?lang=zh`. Preprints are labelled and are not peer reviewed. Last updated 2026-10-15.

Contact: contact@gliostate.com (public contact email; also in the site footer and Organization/WebSite JSON-LD contactPoint).

## Key pages
- [Review: Glioblastoma cell states and AI virtual cells](https://gliostate.com/reviews/gbm-cell-states/): question-led review of Neftel GBM cell states, virtual cell models, GBM digital twins, evidence table and open problems (draft).
- [Field guide](https://gliostate.com/overview/): definitions, milestones, key teams/models, brain tumor progress, critiques and benchmarks.
- [Brain & spinal cord tumors](https://gliostate.com/brain-tumors/): 65 brain-tumor-relevant items grouped by contribution.
- [Research network](https://gliostate.com/research/): knowledge graph hubs (cell states, transitions, models, datasets, perturbations, validation) — each topic page gives research question, current understanding, evidence map and uncertainties.
- [Mesenchymal-like (MES-like) glioblastoma cell state](https://gliostate.com/cell-states/mesenchymal-like/): What is the mesenchymal-like (MES-like) state in glioblastoma?
- [Neural-progenitor-like (NPC-like) and OPC-like glioma cell states](https://gliostate.com/cell-states/neural-progenitor-like-opc-like/): What are NPC-like and OPC-like cells in glioblastoma?
- [Glioblastoma single-cell and spatial datasets](https://gliostate.com/datasets/gbm-single-cell-spatial/): What single-cell and spatial datasets exist for glioblastoma?
- [AI virtual cell models](https://gliostate.com/models/virtual-cell/): What is an AI virtual cell model?
- [Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR](https://gliostate.com/perturbations/gbm-therapy-perturbations/): What perturbation data exist for glioblastoma?
- [Therapy-induced plasticity in glioblastoma](https://gliostate.com/transitions/therapy-induced-plasticity/): Does glioblastoma change cell state after radiotherapy and chemotherapy?
- [Validating virtual cells: benchmarks, baselines and critiques](https://gliostate.com/validation/benchmarks-and-baselines/): How are virtual cell models validated?
- [Do Neftel-style GBM state calls replicate across platforms? A GlioState re-analysis (draft)](https://gliostate.com/validation/gbm-state-call-replication/): Do GBM cell-state calls replicate on an independent platform, and does the state structure go beyond the signature genes?
- [Methods & evidence policy](https://gliostate.com/methods/)
- [About the editorial team](https://gliostate.com/about/): editorial team and editorial/verification policy.

## Data
- [Library](https://gliostate.com/library/): all 139 items; stable anchors like https://gliostate.com/library/#VC0001
- [Library CSV](https://gliostate.com/items.csv): full dataset (id, type, title, authors, date, venue, url, doi, pmid, brain_tumor_focus, tags, bilingual summaries, verification)
- [Library JSON](https://gliostate.com/items.json): normalised (tags as arrays, tag slugs, topic backlinks, related items)
- [Knowledge graph JSON](https://gliostate.com/graph.json): nodes (items, research topics, hubs, tags) and typed edges (cites, evidence, uncertainty, relatedTopic, inHub, hasTag)
- [Knowledge graph JSON-LD](https://gliostate.com/graph.jsonld)
- [Data dictionary](https://gliostate.com/schema.json): field definitions, enums, tag normalisation rules, endpoint list
- Item API: https://gliostate.com/api/items/VC0001.json (one file per item, VC0001…VC0139); example [VC0001](https://gliostate.com/api/items/VC0001.json)
- Topic API: https://gliostate.com/api/topics/<topic-id>.json (one file per research topic), e.g. [cell-state-mes-like](https://gliostate.com/api/topics/cell-state-mes-like.json)
- Raw topic records: https://gliostate.com/data/graph/<file>.json

## Browse
- Paper pages: https://gliostate.com/library/VC0001/ … (one HTML page per item, with JSON-LD, cited-by topics and related papers)
- [Facets index](https://gliostate.com/library/facets/): [tags](https://gliostate.com/library/tag/) (59 tags used ≥2 times), [types](https://gliostate.com/library/type/) (8), [years](https://gliostate.com/library/year/) (13)

## Optional
- [Conferences](https://gliostate.com/conferences/): neuro-oncology and virtual-cell events 2026–2027
- [Full text for LLMs](https://gliostate.com/llms-full.txt)