Divergent genomic evolution in astrocytomas and oligodendrogliomas

GLASS Consortium genomic study (open access; preprint bioRxiv 10.1101/2025.07.11.664189): longitudinal WGS/WES of 183 IDH-mutant glioma patients (94 astrocytomas, 89 oligodendrogliomas). Recurrent oligodendrogliomas acquire PI3K (PIK3CA/PIK3R1) and NOTCH1 mutations with higher TMB; recurrent astrocytomas acquire focal oncogene amplifications and CDKN2A/B homozygous deletions with chromosomal instability (chromothripsis, WGD); temozolomide linked to SBS11/SBS119 in both, radiotherapy-associated ID8 rising in astrocytomas. IDH-mutant, not IDH-wildtype GBM; genomic study with no single-cell state analysis in the paper itself. Data: Synapse syn17038081; code: github.com/verhaaklab/glass-idh.

Authors / organisation

Chowdhury T, Tesileanu CMS, Kocakavuk E, Johnson KC, Lee JH, Erson-Omay Z, Heo C, Aldape K, ... Varn FS, Verhaak RGW; GLASS Consortium.

Venue

Nature

Date

2026-10-14

Type

paper

Year

2026

DOI

10.1038/s41586-026-11150-x

Source

https://www.nature.com/articles/s41586-026-11150-x

Verification

Nature article page (publisher; fetched 2026-10-15: authors, date, abstract, data availability; Europe PMC/Crossref not yet indexed, PMID pending)

GliomaIDHTherapyRadiotherapyastrocytomaoligodendrogliomaGLASSlongitudinalgenomicsWGStemozolomide

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