Hypoxia
Also known as: hypoxic niche · hypoxia-dependent niche
Spatial studies in the library report hypoxia-dependent niches associated with poor prognosis (GBmap), hypoxia coordinating the spatial landscape of myeloid cells in GBM, and cell-state layers that appear driven by hypoxia. VC0060 VC0094 VC0061
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Hypoxia | associated with | Glioblastoma | medium | VC0060 supports VC0094 supports Hypoxia-dependent niches are associated with poor prognosis (GBmap); hypoxia coordinates myeloid-cell spatial organisation. |
| Hypoxia | associated with | Mesenchymal-like state | low | VC0061 supports VC0094 supports The library text says cell-state layers appear driven by hypoxia; it does not tie hypoxia to MES-like specifically. Needs review. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
- Glioblastoma single-cell and spatial datasets (Datasets)
Appears in library items (3)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0060 Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap. — Ruiz-Moreno C et al., Neuro-oncology, 2025
- VC0094 Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival. — Haley MJ et al., Science advances, 2024
- VC0061 Integrative spatial analysis reveals a multi-layered organization of glioblastoma. — Greenwald AC et al., Cell, 2024
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.