{"id":"hypoxia","type":"pathway","name_en":"Hypoxia","name_zh":"缺氧","aliases":["hypoxic niche","hypoxia-dependent niche"],"description":{"en":"Spatial studies in the library report hypoxia-dependent niches associated with poor prognosis (GBmap), hypoxia coordinating the spatial landscape of myeloid cells in GBM, and cell-state layers that appear driven by hypoxia.","zh":"文献库中的空间研究报告：GBmap 中缺氧依赖的生态位与不良预后相关；缺氧协调 GBM 中髓系细胞的空间分布；细胞状态分层似受缺氧驱动。"},"externalIds":{},"graphNames":["hypoxia"],"mentions":{"items":["VC0094"],"topics":["cell-state-mes-like","dataset-gbm-single-cell-spatial"]},"evidenceRefs":["VC0060","VC0094","VC0061"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/hypoxia/","page_url_zh":"https://gliostate.com/zh/entities/hypoxia/","api_url":"https://gliostate.com/api/entities/hypoxia.json","external_links":[],"source_file":"https://gliostate.com/data/entities/hypoxia.json","evidence_items":[{"id":"VC0060","title":"Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap.","year":"2025","page_url":"https://gliostate.com/library/VC0060/","api_url":"https://gliostate.com/api/items/VC0060.json"},{"id":"VC0094","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","year":"2024","page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"},{"id":"VC0061","title":"Integrative spatial analysis reveals a multi-layered organization of glioblastoma.","year":"2024","page_url":"https://gliostate.com/library/VC0061/","api_url":"https://gliostate.com/api/items/VC0061.json"}],"mentioned_in_items":[{"id":"VC0094","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","year":"2024","page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"dataset-gbm-single-cell-spatial","title_en":"Glioblastoma single-cell and spatial datasets","title_zh":"胶质母细胞瘤单细胞与空间数据集","url":"https://gliostate.com/datasets/gbm-single-cell-spatial/","api_url":"https://gliostate.com/api/topics/dataset-gbm-single-cell-spatial.json"}],"relations":[{"subject":"hypoxia","subject_name_en":"Hypoxia","subject_name_zh":"缺氧","predicate":"associated_with","object":"glioblastoma","object_name_en":"Glioblastoma (GBM)","object_name_zh":"胶质母细胞瘤（GBM）","confidence":"medium","evidence":[{"id":"VC0060","role":"supports","title":"Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap.","page_url":"https://gliostate.com/library/VC0060/","api_url":"https://gliostate.com/api/items/VC0060.json"},{"id":"VC0094","role":"supports","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"}],"note":{"en":"Hypoxia-dependent niches are associated with poor prognosis (GBmap); hypoxia coordinates myeloid-cell spatial organisation.","zh":"缺氧依赖的生态位与不良预后相关（GBmap）；缺氧协调髓系细胞的空间分布。"},"sources":[{"kind":"topic","id":"dataset-gbm-single-cell-spatial","url":"https://gliostate.com/datasets/gbm-single-cell-spatial/","api_url":"https://gliostate.com/api/topics/dataset-gbm-single-cell-spatial.json"}]},{"subject":"hypoxia","subject_name_en":"Hypoxia","subject_name_zh":"缺氧","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0061","role":"supports","title":"Integrative spatial analysis reveals a multi-layered organization of glioblastoma.","page_url":"https://gliostate.com/library/VC0061/","api_url":"https://gliostate.com/api/items/VC0061.json"},{"id":"VC0094","role":"supports","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"}],"note":{"en":"The library text says cell-state layers appear driven by hypoxia; it does not tie hypoxia to MES-like specifically. Needs review.","zh":"文献库文本称细胞状态分层似受缺氧驱动，并未将缺氧特异地与 MES 样状态绑定。需复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]}],"related_entities":[{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"relation"},{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"gbmap","type":"dataset","name_en":"GBmap","name_zh":"GBmap","page_url":"https://gliostate.com/entities/gbmap/","page_url_zh":"https://gliostate.com/zh/entities/gbmap/","api_url":"https://gliostate.com/api/entities/gbmap.json","via":"co-mention"},{"id":"neftel-four-state-framework","type":"method","name_en":"Neftel four-state framework","name_zh":"Neftel 四状态框架","page_url":"https://gliostate.com/entities/neftel-four-state-framework/","page_url_zh":"https://gliostate.com/zh/entities/neftel-four-state-framework/","api_url":"https://gliostate.com/api/entities/neftel-four-state-framework.json","via":"co-mention"},{"id":"scrna-seq","type":"method","name_en":"Single-cell RNA sequencing (scRNA-seq)","name_zh":"单细胞 RNA 测序（scRNA-seq）","page_url":"https://gliostate.com/entities/scrna-seq/","page_url_zh":"https://gliostate.com/zh/entities/scrna-seq/","api_url":"https://gliostate.com/api/entities/scrna-seq.json","via":"co-mention"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"co-mention"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"co-mention"}]}