Neftel four-state framework
Also known as: Neftel framework · Neftel et al. 2019
Framework from Neftel et al. (2019), combining single-cell RNA-seq of 28 tumors with bulk data from 401 TCGA specimens: malignant GBM cells occupy four main states (NPC-like, OPC-like, AC-like, MES-like), influenced by microenvironment and plastic. VC0059
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Neftel four-state framework | uses dataset | GSE131928 | medium | VC0059 dataset Accession as stated in the GlioState re-analysis text (Neftel et al. data on GEO). |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
- Neural-progenitor-like (NPC-like) and OPC-like glioma cell states (Cell states)
- Glioblastoma single-cell and spatial datasets (Datasets)
- Do Neftel-style GBM state calls replicate across platforms? A GlioState re-analysis (draft) (Validation)
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.