Iron metabolism (iron uptake and storage programs)
Also known as: iron handling · iron uptake and storage
One library study (Neuro-Oncology 2026) reports that iron uptake and storage programs co-occur with invasion-associated programs in a core-enriched, mesenchymal-like glioblastoma state, and that noncytotoxic iron increased invasion in human cortical slice cultures; the authors state that necessity and mechanism remain to be established. VC0160
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Iron metabolism | associated with | Mesenchymal-like state | medium | VC0160 supports Single study: iron uptake/storage and invasion programs co-occur in a core-enriched MES-like state (single-nucleus RNA-seq with spatial-transcriptomics validation); iron exposure increased invasion in human cortical slice cultures, but the authors state that mechanistic dependence was not tested. Pending editorial review. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0160 Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models — Petry C, Boecke AS, Mohammed AO, Ghariwala NS, Jariwala VD, Shhab MA, Buchholz O, Vasilikos I, Nakagawa JM, Vlachos A, Grauvogel J, Shah MJ, Rölz R, Prinz M, Hofmann UG, Beck J, Joseph K, Ravi VM., Neuro-Oncology, 2026
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.