{"id":"iron-metabolism","type":"pathway","name_en":"Iron metabolism (iron uptake and storage programs)","name_zh":"铁代谢（铁摄取与储存程序）","aliases":["iron handling","iron uptake and storage"],"description":{"en":"One library study (Neuro-Oncology 2026) reports that iron uptake and storage programs co-occur with invasion-associated programs in a core-enriched, mesenchymal-like glioblastoma state, and that noncytotoxic iron increased invasion in human cortical slice cultures; the authors state that necessity and mechanism remain to be established.","zh":"文献库中一项研究（Neuro-Oncology 2026）报告：铁摄取与储存程序与侵袭相关程序共同出现在核心富集的间充质样胶质母细胞瘤状态中，非细胞毒剂量的铁增加了人皮层脑片培养中的侵袭；作者指出其必要性与机制尚待确定。"},"externalIds":{},"graphNames":["iron metabolism"],"mentions":{"items":["VC0160"],"topics":["cell-state-mes-like"]},"evidenceRefs":["VC0160"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/iron-metabolism/","page_url_zh":"https://gliostate.com/zh/entities/iron-metabolism/","api_url":"https://gliostate.com/api/entities/iron-metabolism.json","external_links":[],"source_file":"https://gliostate.com/data/entities/iron-metabolism.json","evidence_items":[{"id":"VC0160","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","year":"2026","page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json"}],"mentioned_in_items":[{"id":"VC0160","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","year":"2026","page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}],"relations":[{"subject":"iron-metabolism","subject_name_en":"Iron metabolism (iron uptake and storage programs)","subject_name_zh":"铁代谢（铁摄取与储存程序）","predicate":"associated_with","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"medium","evidence":[{"id":"VC0160","role":"supports","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json"}],"note":{"en":"Single study: iron uptake/storage and invasion programs co-occur in a core-enriched MES-like state (single-nucleus RNA-seq with spatial-transcriptomics validation); iron exposure increased invasion in human cortical slice cultures, but the authors state that mechanistic dependence was not tested. Pending editorial review.","zh":"单项研究：铁摄取/储存程序与侵袭程序共同出现在核心富集的 MES 样状态中（单核 RNA 测序并经空间转录组验证）；铁暴露增加了人皮层脑片培养中的侵袭，但作者指出未检验机制依赖性。待编辑审阅。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"scrna-seq","type":"method","name_en":"Single-cell RNA sequencing (scRNA-seq)","name_zh":"单细胞 RNA 测序（scRNA-seq）","page_url":"https://gliostate.com/entities/scrna-seq/","page_url_zh":"https://gliostate.com/zh/entities/scrna-seq/","api_url":"https://gliostate.com/api/entities/scrna-seq.json","via":"co-mention"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"co-mention"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"co-mention"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"egfr","type":"gene","name_en":"EGFR (epidermal growth factor receptor)","name_zh":"EGFR（表皮生长因子受体）","page_url":"https://gliostate.com/entities/egfr/","page_url_zh":"https://gliostate.com/zh/entities/egfr/","api_url":"https://gliostate.com/api/entities/egfr.json","via":"co-mention"}]}