65 items marked as directly (yes) or partly (partial) relevant to brain tumors, grouped by what they contribute to a future brain-tumor virtual cell.65 条与脑肿瘤直接相关或部分相关的条目，按其对未来“脑肿瘤虚拟细胞”的贡献分组。
Zaman A et al. · MedComm · 2026-10-04
State-resolved sc+spatial atlas of IDH-associated differences in glioma.IDH相关胶质瘤状态分辨图谱。
Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY. · Genome biology · 2025-12-12
Single-cell atlas of alternative splicing in glioma-immune ecosystem.胶质瘤-免疫生态可变剪接单细胞图谱。
Ruiz-Moreno C et al. · Neuro-oncology · 2025-10-01
GBmap: single-cell & spatial reference atlas of IDH-wt GBM (>1M cells).GBmap：IDH野生型GBM单细胞与空间参考图谱。
Khan SM et al. · bioRxiv · 2025-04-04
Spatial architecture of GBM from core to edge; niche-specific states.GBM核心到边缘的空间结构。
Haley MJ et al. · Science advances · 2024-05-17
Hypoxia coordinates spatial landscape of myeloid cells in GBM.缺氧协调GBM髓系细胞空间格局。
Greenwald AC et al. · Cell · 2024-04-22
Greenwald et al.: multi-layered spatial organization of GBM.Greenwald等：GBM多层次空间组织。
Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA. · Nature cancer · 2022-12-20
Single-cell atlas of GBM evolution under therapy.治疗下GBM演化单细胞图谱。
Ravi VM et al. · Cancer cell · 2022-06-01
Ravi et al.: spatial multi-omics of tumor-host interdependence in GBM.Ravi等：GBM空间多组学揭示肿瘤-宿主相互依存。
Couturier CP et al. · Nature communications · 2020-07-08
Couturier et al.: GBM recapitulates neurodevelopmental hierarchy.GBM重演神经发育层级。
Neftel C et al. · Cell · 2019-07-18
Neftel et al.: four GBM malignant states (NPC/OPC/AC/MES), plasticity and genetics.Neftel等：GBM四种恶性细胞状态及可塑性——虚拟细胞建模的核心“状态空间”。
Venteicher AS et al. · Science (New York, N.Y.) · 2017-03-01
Venteicher et al.: IDH-mutant glioma lineages and microenvironment by scRNA-seq.Venteicher等：IDH突变胶质瘤单细胞谱系。
In vivo Perturb-seq in GBM (with radiotherapy) is currently the closest resource to brain-tumor virtual-cell training data.GBM 体内 Perturb-seq（含放疗）是目前最接近“脑肿瘤虚拟细胞训练数据”的资源。
Sun R et al. · Nature · 2026-09-09
Nature 2026: operational perturbation-proteomics-based virtual cell model.Nature 2026：基于扰动蛋白质组的可操作虚拟细胞模型。
Zhang J et al. · Cell · 2026-09-01
Tahoe-100M peer-reviewed (Cell 2026).Tahoe-100M正式发表于Cell 2026。
Adduri AK et al. · Cell · 2026-08-31
State (Arc Institute): state-embedding + transition model across 70 contexts; Cell 2026.Arc的State模型：跨70种细胞情境预测扰动反应（Cell 2026）。
Melhem A et al. · Nature protocols · 2026-07-28
Core2Edge: GBM organoid-brain slice infiltration model (Nat Protoc).Core2Edge：GBM类器官-脑片浸润模型。
Jungwirth G et al. · NPJ precision oncology · 2026-06-16
Automated personalized GBM organoid drug screening platform.自动化个体化GBM类器官药筛平台。
Suter et al. · Nature Communications · 2026-01-07
scFOCAL/ISOSCELES links GBM cell states to L1000 signatures; predicts state-specific sensitivity and OLIG2i+Depatux-M combo.scFOCAL/ISOSCELES：把GBM细胞状态接到L1000药签，预测状态敏感度并验证OLIG2抑制剂+Depatux-M。
Vadla R et al. · Neuro-oncology · 2025-11-01
BRD2 regulates GBM cell-state plasticity and therapy response.BRD2调控GBM状态可塑性与治疗反应。
Peng et al. · preprint · 2025-09-17
DELPHAI: AI agent for sc perturbation prediction + LLM mechanism on GBM organoids with TMZ; OT+PCA beat baselines.DELPHAI：GBM类器官+TMZ的单细胞扰动预测与LLM机制解读；最优传输+PCA优于基线。
Adduri AK et al. · bioRxiv · 2025-06-27
State preprint (bioRxiv June 2025).State模型预印本。
Hara T et al. · Cancer cell · 2025-05-27
Hara et al.: immune–cancer interactions drive MES-like transitions in GBM.免疫细胞驱动GBM向间充质样状态转变。
Kint S et al. · bioRxiv · 2025-05-14
Spatial epigenomic niches underlie GBM cell-state plasticity.空间表观生态位决定GBM状态可塑性。
Zhang J et al. · bioRxiv · 2025-02-24
Tahoe-100M preprint: 100M cells, 1,100 drugs x 50 cancer cell lines.Tahoe-100M：1亿细胞、1100药物×50肿瘤细胞系。
Sun R, Qian L, Li Y, Cheng H, Xue Z, Zhang X, Tan L, Zhan Y, Hu W, Xiao Q, Liu Z, Zhang G, Weinan E, Zhou P, Wen H, Zhu Y, Guo T. · bioRxiv · 2025-02-10
Preprint of the perturbation-proteomics foundation model for virtual cells.上述扰动蛋白组虚拟细胞模型预印本。
Liu SJ et al. · Genome biology · 2024-10-07
In vivo Perturb-seq of GBM and microenvironment dissects drivers and radiotherapy responses.GBM体内Perturb-seq：解析驱动基因与放疗反应——脑肿瘤虚拟细胞的关键训练数据类型。
Jacob F et al. · Cell · 2019-12-26
Jacob et al.: patient-derived GBM organoid biobank (GBO).Jacob等：患者来源GBM类器官库。
Laslo D et al. · BMC medicine · 2026-05-18
Generative AI forecasting spatial tumor growth on MRI in pediatric DMG.生成式AI预测儿童DMG的MRI空间生长。
Kapteyn et al. · BMC Med Inform Decis Mak · 2026-05-11
Open modular Python framework for patient-specific tumor digital twins; HGG growth/RT response demo.开源模块化Python肿瘤数字孪生框架；演示高级别胶质瘤生长与放疗反应。
Mayfield JD. · bioRxiv · 2026-04-23
Proteome-calibrated mechanistic digital twin of the GBM astrocyte (bioRxiv 2026).蛋白质组校准的GBM星形细胞机制性数字孪生（预印本）。
Malik et al. · PLoS Comput Biol · 2026-01-20
Patient-specific GBM xenograft growth/invasion model on mouse brain anatomy; ABC fit; treatment via parameter perturbation.基于小鼠脑解剖的患者特异性GBM异种移植生长/侵袭模型；ABC拟合；通过扰动参数模拟治疗。
Liu Z, Zhang J, Hong L, Nie Q, Sun X. · Science advances · 2025-08-08
Multiscale mechanistic model + reinforcement learning to optimize glioma combination scheduling.多尺度机制模型+强化学习优化胶质瘤联合治疗时序。
Johnson JAI et al. · Cell · 2025-07-26
Human-interpretable grammar for multicellular agent-based models (PhysiCell) to democratize virtual cell labs.可解释“语法”驱动的多细胞主体模型，降低虚拟细胞实验室门槛（含肿瘤示例）。
Vieira Junior MG, de Almeida Côrtes AM, Gonçalves Carneiro FR, Carels N, Silva FABD. · Scientific reports · 2024-10-29
In silico exploration of GBM attractors from scRNA-seq (Boolean network).基于单细胞数据的GBM吸引子计算探索。
Saucedo-Mora L, Sanz MÁ, Montáns FJ, Benítez JM. · Computer methods and programs in biomedicine · 2024-01-26
Agent-based hybrid model of GBM cell biophysics and treatment.GBM细胞生物物理主体模型。
Engwer C, Hillen T, Knappitsch M, Surulescu C. · Journal of mathematical biology · 2014-09-12
Multiscale DTI-based glioma spread model.基于DTI的多尺度胶质瘤扩散模型。
Swanson KR, Bridge C, Murray JD, Alvord EC. · Journal of the neurological sciences · 2003-12-01
Swanson et al.: 'virtual and real brain tumors' — classic proliferation-invasion model.Swanson等：“虚拟脑肿瘤”经典增殖-侵袭模型。
Brain-tumor “foundation models” are so far concentrated in MRI and pathology; no peer-reviewed study was found applying single-cell foundation models to glioma perturbation prediction.脑肿瘤领域的“基础模型”目前集中在 MRI 与病理；尚未检索到将单细胞基础模型用于胶质瘤扰动预测的同行评审论文。
Li J, Liu R, Xing Y, Gao X, Yin Q, Su Q. · JCO precision oncology · 2026-02-20
MRI foundation model for brain tumor molecular profiling and progression.基于常规MRI的脑肿瘤分子分型基础模型。
Li J, Liu R, Xing Y, Gao X, Yin Q, Su Q. · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025-11-19
Foundation model for brain tumor MRI: WHO grading & subtyping.脑肿瘤MRI基础模型：WHO分级与亚型。
Huang T, Liu T, Babadi M, Ying R, Jin W. · NPJ digital medicine · 2025-11-14
STPath: generative model linking WSIs and spatial transcriptomics.STPath：整合全切片图像与空间转录组的生成模型。
Chen W et al. · Nature methods · 2025-05-29
OmiCLIP/Loki: visual-omics foundation model bridging H&E and spatial transcriptomics.病理图像与空间转录组桥接的视觉-组学基础模型。
Rizvi SA et al. · bioRxiv · 2025-04-17
C2S-Scale (Yale/Google): scaling LLMs to 27B for single-cell analysis and virtual screening.C2S-Scale（耶鲁/谷歌）：270亿参数单细胞LLM，含虚拟药物筛选。
Chen RJ et al. · Nature medicine · 2024-03-19
UNI: general-purpose computational pathology foundation model (incl. brain tumor tasks).UNI：通用病理基础模型（含脑肿瘤分型任务）。
Bioptimus · Bioptimus news · date n/a日期未注明
French startup building multiscale biology FMs (H-Optimus pathology models).法国Bioptimus多尺度生物基础模型。
Yang Y, Gao Y, Qi Z, Li S, Wang Z, Li D, Chen L, Zhou C, Feng M, Chen X, Hao B, Wu X, Li L, Cao Y. · Journal of translational medicine · 2026-06-16
Oligodendrocyte fatty-acid remodeling in brain metastasis (sc+spatial).脑转移中少突胶质细胞脂肪酸代谢重塑。
Tagore S et al. · Nature medicine · 2025-02-27
Single-cell & spatial landscape of NSCLC brain metastases (Nat Med 2025).非小细胞肺癌脑转移单细胞与空间图谱。
Wang Z, Wang Y, Chang M, Wang Y, Liu P, Wu J, Wang G, Tang X, Hui X, Liu P, Guo X, Xing B, Wang Y, Han Z, Ma W. · Neuro-oncology · 2023-07-01
Cellular origins and drivers of brain metastasis by scRNA-seq.脑转移细胞起源与驱动。
Zhang Q, Abdo R, Iosef C, Kaneko T, Cecchini M, Han VK, Li SS. · Nature communications · 2022-10-10
Spatial transcriptomic landscape of NSCLC brain metastasis.肺癌脑转移空间转录组。
Chen M, Duan B, Zhang J, Daniels C, Hu C, Yuan J, Guo J, Taylor MD, Shi X, Zhang L, Li D, Sun T. · Journal of translational medicine · 2026-09-15
Spatial + single-cell dissection of medulloblastoma hierarchies (2026).髓母细胞瘤空间与单细胞层级（2026）。
Li W, Sun X, Pei S. · BMC medicine · 2026-08-12
Critique of the DMG generative growth study (domain shift, nesting).对上述DMG生成模型的方法学批评。
Sussman JH et al. · Cell reports. Medicine · 2026-04-23
Longitudinal single-cell & spatial atlas of pediatric high-grade glioma.儿童高级别胶质瘤纵向单细胞/空间图谱。
Ellenbogen Y, Landry AP, Yefet LS, Ajisebutu A, Gui C, Persaud P, Kaloti R, Nassiri F. · Neuro-oncology advances · 2026-02-27
Review: current landscape of single-cell genomics in meningioma.综述：脑膜瘤单细胞基因组学现状。
Lee JY, Lee EJ, Seo BY, Kim J, Song Y, Lee D, Moon N, Koo H, Park CK, Kim MS, Park SI, Nam DH, Kong DS, Sa JK. · Nature communications · 2025-07-01
Longitudinal single-cell trajectory of meningioma evolution.脑膜瘤纵向单细胞演化轨迹。
Liu I et al. · Nature genetics · 2022-12-05
Liu et al.: tumor cell states and spatial organization of H3-K27M DMG across ages.H3-K27M弥漫中线胶质瘤跨年龄细胞状态与空间组织。
Wang AZ et al. · Genome medicine · 2022-05-10
Single-cell profiling of human dura and meningioma.硬脑膜与脑膜瘤单细胞图谱。
Zhang L et al. · Cancer cell · 2019-08-29
Vladoiu et al.: medulloblastoma progenitors & developmental origins.髓母细胞瘤起源祖细胞。
Hovestadt V et al. · Nature · 2019-07-24
Hovestadt et al.: medulloblastoma cellular architecture by single-cell genomics.髓母细胞瘤单细胞结构。
Filbin MG et al. · Science (New York, N.Y.) · 2018-04-01
Filbin et al.: OPC-like programs in H3K27M gliomas.Filbin等：H3K27M胶质瘤的发育与致瘤程序。
Spinal cord intramedullary tumors (ependymoma, astrocytoma) have almost no single-cell atlases and, as of this review, no virtual cell studies. No item in the library addresses them yet — this is the gap GlioState intends to track and help fill.脊髓髓内肿瘤（室管膜瘤、星形细胞瘤）几乎没有单细胞图谱，截至本轮综述也没有虚拟细胞研究。文献库中尚无相关条目——这正是 GlioState 计划持续追踪并参与填补的空白。
No items yet. Suggestions welcome.暂无条目，欢迎推荐。
AACR · Orlando, FL (to Apr 7) · 2027-04-02
AACR 2027, Apr 2-7, Orlando.AACR 2027：4月2-7日奥兰多。
NeurIPS · NeurIPS 2026, Sydney · 2026-12-11
NeurIPS 2026 workshop on FMs for brain and body (Dec 11-12, Sydney).NeurIPS 2026脑与身体基础模型研讨会。
Society for Neuro-Oncology · Philadelphia, PA (to Nov 15) · 2026-11-12
SNO 2026, Nov 12-15, Philadelphia; SNO 2027 Nov 18-21 Phoenix.SNO 2026：11月12-15日费城；2027年11月18-21日凤凰城。
European Association of Neuro-Oncology · Rome, Italy (to Sep 27) · 2026-09-24
EANO 2026 Sep 24-27, Rome (already passed).EANO 2026：9月24-27日罗马（已结束）。
Pear Healthcare Playbook · Substack · 2026-06-30
Interview on Noetik's virtual cell foundation models licensed to GSK.Noetik CEO访谈。
Latent Space · Latent Space podcast · 2026
Noetik's tumor spatial 'virtual cell' models (TARIO-2) and $50M GSK deal.Noetik肿瘤空间虚拟细胞模型TARIO-2与GSK合作。
Yang T, Wang YY, Ma F, Xu BH, Qian HL. · Military Medical Research · 2025-01-27
Commentary on building virtual cells for cancer research (Chinese authors).面向肿瘤研究的虚拟细胞评论（中国团队）。
CZI Cell Science Program et al. · Nucleic acids research · 2025-01-01
CZ CELLxGENE Discover: 100M+ cell data platform (contains glioma datasets).CZ CELLxGENE：超1亿细胞的数据平台（含胶质瘤数据集）。
Yes, but they are early and few. Examples include scFOCAL/ISOSCELES, which links glioblastoma cell states to drug signatures, the DELPHAI preprint on temozolomide response in GBM organoids, and a proteome-calibrated mechanistic “digital twin” of the GBM astrocyte (preprint). In vivo Perturb-seq in GBM provides the kind of paired perturbation data such models need.有，但仍处于早期且数量很少。例如：将 GBM 细胞状态与药物特征谱关联的 scFOCAL/ISOSCELES、预测 GBM 类器官替莫唑胺反应的 DELPHAI（预印本），以及蛋白组校准的 GBM 星形细胞机制性“数字孪生”（预印本）。GBM 体内 Perturb-seq 则提供了此类模型所需的配对扰动数据。 VC0132 VC0129 (preprint)（预印本） VC0071 (preprint)（预印本） VC0070
Not that we could find. As of this review, the library contains no single-cell atlas or virtual cell study specific to spinal cord intramedullary tumors such as ependymoma or astrocytoma. GlioState tracks this as an open gap.目前未检索到。截至本轮整理，文献库中尚无针对脊髓髓内肿瘤（如室管膜瘤、星形细胞瘤）的单细胞图谱或虚拟细胞研究。GlioState 将其作为研究空白持续追踪。
Mainly single-cell and spatial atlases plus perturbation experiments. GBmap integrates more than one million cells into a single-cell and spatial reference atlas, and a single-cell atlas of GBM under therapy captures treatment-related change. Paired perturbation data in GBM remain scarce, with in vivo Perturb-seq a notable exception.主要是单细胞与空间图谱以及扰动实验数据。GBmap 整合了逾百万个细胞的单细胞与空间参考图谱；GBM 治疗下的单细胞图谱记录了治疗相关变化。GBM 的配对扰动数据仍很稀缺，体内 Perturb-seq 是少数例外。 VC0060 VC0069 VC0070