Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
scFOCAL/ISOSCELES links GBM cell states to L1000 signatures; predicts state-specific sensitivity and OLIG2i+Depatux-M combo.
- Authors / organisation
- Suter et al.
- Venue
- Nature Communications
- Date
- 2026-01-07
- Type
- paper
- Year
- 2026
- DOI
- 10.1038/s41467-025-67783-5
- Verification
- Crossref
Cited by GlioState topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
- Neural-progenitor-like (NPC-like) and OPC-like glioma cell states (Cell states)
- AI virtual cell models (Models)
- Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR (Perturbations)
- Therapy-induced plasticity in glioblastoma (Transitions)
Entities mentioned
- Glioblastoma Diseases
- LINCS L1000 drug signatures Datasets
- OLIG2 Genes
- scFOCAL / ISOSCELES Models
- Single-cell RNA sequencing Methods & concepts