Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution.
Zhang J et al. · Cell · 2026-09-01
Tahoe-100M peer-reviewed (Cell 2026).
Tag: Drug response
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PerturbLDM: conditional latent diffusion for modelling single-cell perturbation responses
Yu et al. · bioRxiv · 2026-08-12
PerturbLDM: Tahoe-100M-pretrained latent diffusion for conditional sc response generation across drug/dose/cell-line.
Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.
Jungwirth G et al. · NPJ precision oncology · 2026-06-16
Automated personalized GBM organoid drug screening platform.
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
Suter et al. · Nature Communications · 2026-01-07
scFOCAL/ISOSCELES links GBM cell states to L1000 signatures; predicts state-specific sensitivity and OLIG2i+Depatux-M combo.
DELPHAI, AI Agent for Predicting Drug Response and Resistance
Peng et al. · preprint · 2025-09-17
DELPHAI: AI agent for sc perturbation prediction + LLM mechanism on GBM organoids with TMZ; OT+PCA beat baselines.
Tahoe-100M : A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
Zhang J et al. · bioRxiv · 2025-02-24
Tahoe-100M preprint: 100M cells, 1,100 drugs x 50 cancer cell lines.
Predicting cellular responses to complex perturbations in high-throughput screens.
Lotfollahi M et al. · Molecular systems biology · 2023-05-08
CPA: compositional perturbation autoencoder for drug/dose/combination responses.