Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity With High-Density Progenitor Cell Regions Correlating With High-Risk Disease

Chien et al. (Emory / Children's Healthcare of Atlanta, with NYU Langone; JCO Precision Oncology 2026): spatial transcriptomics of 18 pediatric medulloblastoma samples obtained at diagnosis, including two matched diagnosis–relapse pairs, stratified into high- and standard-risk groups; dense regions of quiescent progenitor-like tumor cells were enriched in high-risk patients, and tumor-associated astrocytes, macrophages and dysregulated vascular endothelium increased after relapse; immunohistochemistry validation in the same cohort. Small cohort with only two relapse pairs; no external validation cohort is stated.

Authors / organisation

Chien F, Michaud ME, Bakhtiari M, Schroff C, Snuderl M, Velazquez Vega JE, MacDonald TJ, Bhasin MK.

Venue

JCO Precision Oncology

Date

2026-10-13

Type

paper

Year

2026

DOI

10.1200/po-25-01195

PMID

42868339

Verification

PubMed E-utilities PMID 42868339 (title, 8 authors, Emory/NYU affiliations, JCO Precis Oncol, epub 2026-10-13, abstract) + Crossref (journal-article, vol 10, e2501195, issue 2026-10) fetched 2026-10-20; full text not read

MedulloblastomaSpatial omicsImmune

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