{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"human","system":"human_tissue","evidence_level":"peer_reviewed","importance":"","importance_reason":""},"id":"VC0162","type":"paper","title":"Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity With High-Density Progenitor Cell Regions Correlating With High-Risk Disease","authors_or_org":"Chien F, Michaud ME, Bakhtiari M, Schroff C, Snuderl M, Velazquez Vega JE, MacDonald TJ, Bhasin MK.","date":"2026-10-13","year":"2026","venue":"JCO Precision Oncology","url":"https://doi.org/10.1200/po-25-01195","doi":"10.1200/po-25-01195","pmid":"42868339","brain_tumor_focus":"yes","tags":["medulloblastoma","spatial","immune"],"tag_slugs":["medulloblastoma","spatial","immune"],"tag_labels":["Medulloblastoma","Spatial omics","Immune"],"tag_labels_zh":["髓母细胞瘤","空间组学","免疫"],"unmapped_tags":[],"one_line_summary_en":"Chien et al. (Emory / Children's Healthcare of Atlanta, with NYU Langone; JCO Precision Oncology 2026): spatial transcriptomics of 18 pediatric medulloblastoma samples obtained at diagnosis, including two matched diagnosis–relapse pairs, stratified into high- and standard-risk groups; dense regions of quiescent progenitor-like tumor cells were enriched in high-risk patients, and tumor-associated astrocytes, macrophages and dysregulated vascular endothelium increased after relapse; immunohistochemistry validation in the same cohort. Small cohort with only two relapse pairs; no external validation cohort is stated.","one_line_summary_zh":"Chien 等（Emory/亚特兰大儿童医疗中心，联合 NYU Langone；JCO Precision Oncology 2026）：对 18 例儿童髓母细胞瘤初诊样本（含 2 对初诊–复发配对）做空间转录组，并按高危/标危分层；高危患者中富集致密的静息祖细胞样肿瘤细胞区域，复发后肿瘤相关星形胶质细胞、巨噬细胞及失调血管内皮增多；在同一队列中以免疫组化验证。样本量小，仅 2 对复发配对；未提及外部验证队列。","verified":"yes","verification_source":"PubMed E-utilities PMID 42868339 (title, 8 authors, Emory/NYU affiliations, JCO Precis Oncol, epub 2026-10-13, abstract) + Crossref (journal-article, vol 10, e2501195, issue 2026-10) fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0162/","api_url":"https://gliostate.com/api/items/VC0162.json","sameAs":["https://doi.org/10.1200/po-25-01195","https://pubmed.ncbi.nlm.nih.gov/42868339/"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/medulloblastoma/","https://gliostate.com/library/tag/spatial/","https://gliostate.com/library/tag/immune/"]},"cited_by":[],"related":[{"id":"VC0161","title":"Point-Process Modelling of Cell-Type Interaction Structure in CosMx Glioma Data for Hypothesis-Driven Tumor Inference from scRNA-seq","shared_tags":["spatial","immune"],"page_url":"https://gliostate.com/library/VC0161/","api_url":"https://gliostate.com/api/items/VC0161.json"},{"id":"VC0081","title":"Spatial and single-cell dissection of medulloblastoma identifies developmental hierarchies and a prognostic PPIA-BSG tumor-immune axis.","shared_tags":["medulloblastoma","spatial"],"page_url":"https://gliostate.com/library/VC0081/","api_url":"https://gliostate.com/api/items/VC0081.json"},{"id":"VC0094","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","shared_tags":["immune","spatial"],"page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["immune"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0080","title":"Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.","shared_tags":["medulloblastoma"],"page_url":"https://gliostate.com/library/VC0080/","api_url":"https://gliostate.com/api/items/VC0080.json"},{"id":"VC0079","title":"Resolving medulloblastoma cellular architecture by single-cell genomics.","shared_tags":["medulloblastoma"],"page_url":"https://gliostate.com/library/VC0079/","api_url":"https://gliostate.com/api/items/VC0079.json"}]}