{"id":"VC0140","type":"paper","title":"Divergent genomic evolution in astrocytomas and oligodendrogliomas","authors_or_org":"Chowdhury T, Tesileanu CMS, Kocakavuk E, Johnson KC, Lee JH, Erson-Omay Z, Heo C, Aldape K, ... Varn FS, Verhaak RGW; GLASS Consortium.","date":"2026-10-14","year":"2026","venue":"Nature","url":"https://www.nature.com/articles/s41586-026-11150-x","doi":"10.1038/s41586-026-11150-x","pmid":"","brain_tumor_focus":"yes","tags":["glioma","IDH-mutant","astrocytoma","oligodendroglioma","GLASS","longitudinal","genomics","WGS","therapy","temozolomide","radiotherapy"],"tag_slugs":["glioma","idh","therapy","radiotherapy"],"tag_labels":["Glioma","IDH","Therapy","Radiotherapy"],"tag_labels_zh":["胶质瘤","IDH 突变","治疗","放射治疗"],"unmapped_tags":["astrocytoma","oligodendroglioma","GLASS","longitudinal","genomics","WGS","temozolomide"],"one_line_summary_en":"GLASS Consortium genomic study (open access; preprint bioRxiv 10.1101/2025.07.11.664189): longitudinal WGS/WES of 183 IDH-mutant glioma patients (94 astrocytomas, 89 oligodendrogliomas). Recurrent oligodendrogliomas acquire PI3K (PIK3CA/PIK3R1) and NOTCH1 mutations with higher TMB; recurrent astrocytomas acquire focal oncogene amplifications and CDKN2A/B homozygous deletions with chromosomal instability (chromothripsis, WGD); temozolomide linked to SBS11/SBS119 in both, radiotherapy-associated ID8 rising in astrocytomas. IDH-mutant, not IDH-wildtype GBM; genomic study with no single-cell state analysis in the paper itself. Data: Synapse syn17038081; code: github.com/verhaaklab/glass-idh.","one_line_summary_zh":"GLASS 联盟基因组学研究（开放获取；预印本 bioRxiv 10.1101/2025.07.11.664189）：对 183 例 IDH 突变型胶质瘤患者（94 例星形细胞瘤、89 例少突胶质细胞瘤）进行纵向 WGS/WES。复发少突胶质细胞瘤新获 PI3K（PIK3CA/PIK3R1）与 NOTCH1 突变并伴更高 TMB；复发星形细胞瘤新获局灶癌基因扩增和 CDKN2A/B 纯合缺失并伴染色体不稳定（chromothripsis、WGD）；替莫唑胺在两型中均与 SBS11/SBS119 相关，放疗相关 ID8 特异性见于星形细胞瘤。研究对象为 IDH 突变型而非 IDH 野生型 GBM；论文本身为基因组学研究，不含单细胞状态分析。数据：Synapse syn17038081；代码：github.com/verhaaklab/glass-idh。","verified":"yes","verification_source":"Nature article page (publisher; fetched 2026-10-15: authors, date, abstract, data availability; Europe PMC/Crossref not yet indexed, PMID pending)","page_url":"https://gliostate.com/library/VC0140/","api_url":"https://gliostate.com/api/items/VC0140.json","sameAs":["https://doi.org/10.1038/s41586-026-11150-x","https://www.nature.com/articles/s41586-026-11150-x"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/glioma/","https://gliostate.com/library/tag/idh/","https://gliostate.com/library/tag/therapy/","https://gliostate.com/library/tag/radiotherapy/"]},"cited_by":[{"id":"transition-therapy-induced-plasticity","type":"transition","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"related":[{"id":"VC0134","title":"TumorTwin: a Python framework for patient-specific digital twins in oncology","shared_tags":["glioma","radiotherapy"],"page_url":"https://gliostate.com/library/VC0134/","api_url":"https://gliostate.com/api/items/VC0134.json"},{"id":"VC0141","title":"Acquired genetic and cell-state changes in IDH-mutant glioma progression","shared_tags":["glioma","idh"],"page_url":"https://gliostate.com/library/VC0141/","api_url":"https://gliostate.com/api/items/VC0141.json"},{"id":"VC0073","title":"Multiscale mathematical model-informed reinforcement learning optimizes combination treatment scheduling in glioblastoma evolution.","shared_tags":["glioma","therapy"],"page_url":"https://gliostate.com/library/VC0073/","api_url":"https://gliostate.com/api/items/VC0073.json"},{"id":"VC0070","title":"In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.","shared_tags":["radiotherapy"],"page_url":"https://gliostate.com/library/VC0070/","api_url":"https://gliostate.com/api/items/VC0070.json"},{"id":"VC0090","title":"A State-Resolved Single-Cell and Spatial Atlas Reveals IDH-Associated Differences in Malignant and Immune Architecture in Diffuse Glioma.","shared_tags":["idh"],"page_url":"https://gliostate.com/library/VC0090/","api_url":"https://gliostate.com/api/items/VC0090.json"},{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","shared_tags":["therapy"],"page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}]}