In silico perturbation
Also known as: in silico deletion · ISP
Computational prediction of the effect of perturbing genes in a trained model, for example Geneformer in silico deletion; a Nature Protocols article describes discovering candidate therapeutic targets this way, and ISP3 extends it to sequential multi-gene perturbation. VC0009 VC0010 VC0038 · preprint
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Geneformer | associated with | In silico perturbation | high | VC0009 supports VC0010 supports VC0038 · preprint supports From: AI virtual cell models · entity record |
Appears in research topics
Not yet mentioned in a research topic page.
Appears in library items (3)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0038 · preprint ISP 3 Platform powered by Geneformer: Framework for Cross-Species, Sequential, and Multi-Gene In Silico Perturbation Screens with Application to iPS Cell State Transitions — Sanaki Y, Shigenobu S, Niwa R., bioRxiv, 2026
- VC0010 Discovery of candidate therapeutic targets with Geneformer. — Zhang Y, Venkatesh MS, Theodoris CV., Nature protocols, 2026
- VC0009 Transfer learning enables predictions in network biology. — Theodoris CV, Xiao L, Chopra A, Chaffin MD, Al Sayed ZR, Hill MC, Mantineo H, Brydon EM, Zeng Z, Liu XS, Ellinor PT., Nature, 2023
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.