The library includes a harmonised GBM reference atlas (GBmap, >1.1 million cells from 240 patients), primary–recurrent and spatial studies, and a GBM organoid biobank. Observational atlases are plentiful; paired perturbation data are scarce.
VC0096 Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion. — Melhem A et al., Nature protocols, 2026
VC0060 Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap. — Ruiz-Moreno C et al., Neuro-oncology, 2025
VC0093 · preprint Spatial epigenomic niches underlie glioblastoma cell state plasticity — Kint S et al., bioRxiv, 2025
VC0092 · preprint Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions — Khan SM et al., bioRxiv, 2025
VC0043 CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data. — CZI Cell Science Program et al., Nucleic acids research, 2025
VC0070 In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma. — Liu SJ et al., Genome biology, 2024
VC0094 Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival. — Haley MJ et al., Science advances, 2024
VC0061 Integrative spatial analysis reveals a multi-layered organization of glioblastoma. — Greenwald AC et al., Cell, 2024
VC0069 A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets. — Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA., Nature cancer, 2022
VC0062 Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. — Ravi VM et al., Cancer cell, 2022
VC0067 A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. — Jacob F et al., Cell, 2019
VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019