{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"unknown","system":"in_silico","evidence_level":"preprint","importance":"","importance_reason":""},"id":"VC0177","type":"preprint","title":"SHAPPEing agent-based models to spatial data: Sequential Hooke's law Algorithm for Point Pattern reconstruction with Environmental constraints","authors_or_org":"Mongeon B, Craig M.","date":"2026-10-16","year":"2026","venue":"bioRxiv (preprint, not peer-reviewed)","url":"https://doi.org/10.64898/2026.10.14.759208","doi":"10.64898/2026.10.14.759208","pmid":"","brain_tumor_focus":"yes","tags":["gbm","simulation","spatial","immune","mechanistic"],"tag_slugs":["gbm","simulation","spatial","immune","mechanistic"],"tag_labels":["GBM","Simulation","Spatial omics","Immune","Mechanistic & agent-based model"],"tag_labels_zh":["胶质母细胞瘤","模拟仿真","空间组学","免疫","机制与基于主体的模型"],"unmapped_tags":[],"one_line_summary_en":"Preprint (not peer-reviewed): Mongeon and Craig (Université de Montréal) present SHAPPE, a multitype point-pattern reconstruction algorithm that generates synthetic spatial configurations of arbitrary size from small imaging regions, used to initialise agent-based models. On 87 glioblastoma imaging mass cytometry samples, the authors report that SHAPPE reduced dissimilarity in density distributions by a median of 53% and inter-cell-type exposure errors by 34% relative to a random baseline. Initialising a glioblastoma ABM with SHAPPE instead of random placement reduced tumour–CD8+ T cell interaction frequency and lowered the average number of tumour cells killed by CD8+ T cells over 50 simulated days by over 20%.","one_line_summary_zh":"预印本（未经同行评审）：Mongeon 与 Craig（蒙特利尔大学）提出 SHAPPE，一种多类型点模式重建算法，可从小块成像区域生成任意尺寸的合成空间布局，用于初始化基于主体的模型（ABM）。在 87 个胶质母细胞瘤成像质谱流式（IMC）样本上，作者报告 SHAPPE 相比随机基线使密度分布差异中位数降低 53%、细胞类型间暴露误差降低 34%。用 SHAPPE 代替随机布点初始化胶质母细胞瘤 ABM 后，肿瘤–CD8+ T 细胞相互作用频率下降，50 天模拟中 CD8+ T 细胞平均杀伤的肿瘤细胞数减少逾 20%。","verified":"yes","verification_source":"bioRxiv API details (title, 2 authors, posted 2026-10-16, v1, new results, systems biology, CC BY-NC, Université de Montréal, abstract) fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0177/","api_url":"https://gliostate.com/api/items/VC0177.json","sameAs":["https://doi.org/10.64898/2026.10.14.759208"],"is_preprint":true,"facets":{"type":"https://gliostate.com/library/type/preprint/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/simulation/","https://gliostate.com/library/tag/spatial/","https://gliostate.com/library/tag/immune/","https://gliostate.com/library/tag/mechanistic/"]},"cited_by":[],"related":[{"id":"VC0121","title":"SIMBIOCHEM II · NeurIPS 2026 Workshop on ML for Simulation","shared_tags":["simulation"],"page_url":"https://gliostate.com/library/VC0121/","api_url":"https://gliostate.com/api/items/VC0121.json"},{"id":"VC0113","title":"AIDO Cell: a general-purpose simulator for cell biology","shared_tags":["simulation"],"page_url":"https://gliostate.com/library/VC0113/","api_url":"https://gliostate.com/api/items/VC0113.json"},{"id":"VC0161","title":"Point-Process Modelling of Cell-Type Interaction Structure in CosMx Glioma Data for Hypothesis-Driven Tumor Inference from scRNA-seq","shared_tags":["gbm","spatial","immune"],"page_url":"https://gliostate.com/library/VC0161/","api_url":"https://gliostate.com/api/items/VC0161.json"},{"id":"VC0094","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","shared_tags":["gbm","immune","spatial"],"page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"},{"id":"VC0162","title":"Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity With High-Density Progenitor Cell Regions Correlating With High-Risk Disease","shared_tags":["spatial","immune"],"page_url":"https://gliostate.com/library/VC0162/","api_url":"https://gliostate.com/api/items/VC0162.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["gbm","immune"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"}]}