{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"human","system":"unknown","evidence_level":"preprint","importance":"","importance_reason":""},"id":"VC0176","type":"preprint","title":"A multimodal precision oncology platform integrating genomics, single-cell transcriptomics, and functional drug screening expands therapeutic options in pediatric brain tumors","authors_or_org":"Huang X, Qiao Y, Black GS, Sederman CR, Yang H, Musci T, Ludwick A, He G, Youssef O, Gutierrez M, Yang J, Chan PP, Memmott TH, Whipple NS, Bruggers CS, Quinlan A, Moos PJ, Cheshier SH, Marth GT.","date":"2026-10-14","year":"2026","venue":"bioRxiv (preprint, not peer-reviewed)","url":"https://doi.org/10.64898/2026.10.12.758619","doi":"10.64898/2026.10.12.758619","pmid":"","brain_tumor_focus":"yes","tags":["neuro-oncology","scrna-seq","drug-response","therapy","platform"],"tag_slugs":["neuro-oncology","scrna-seq","drug-response","therapy","platform"],"tag_labels":["Neuro-oncology","scRNA-seq","Drug response","Therapy","Platform"],"tag_labels_zh":["神经肿瘤学","单细胞 RNA 测序","药物反应","治疗","平台"],"unmapped_tags":[],"one_line_summary_en":"Preprint (not peer-reviewed): Huang et al. (University of Utah; senior authors Cheshier SH and Marth GT) describe a tiered framework combining deep whole-genome sequencing, scRNA-seq and ex vivo functional drug screening, applied to 17 children with malignant CNS tumors. Functional screening gave every patient at least one high-confidence targeted-therapy or chemotherapy nomination; scRNA-seq identified on average 37 druggable gene targets per patient, a fourfold increase in high-confidence targeted-therapy recommendations. In an exploratory analysis, functional classifications were directionally consistent with outcomes in 8 of 10 evaluable cases, but combination treatments and radiation precluded causal attribution.","one_line_summary_zh":"预印本（未经同行评审）：Huang 等（犹他大学；资深作者 Cheshier SH 与 Marth GT）提出分层框架，结合深度全基因组测序、单细胞 RNA 测序与离体功能性药物筛选，应用于 17 名恶性中枢神经系统肿瘤患儿。功能筛选为每位患者至少提供一个高置信度的靶向药或化疗候选；单细胞测序平均每位患者发现 37 个可成药基因靶点，使高置信度靶向治疗推荐增加至四倍。探索性分析中，10 例可评估病例里有 8 例的功能分类与结局方向一致，但联合治疗与放疗使因果归因无法成立。","verified":"yes","verification_source":"bioRxiv API details (title, 19 authors, posted 2026-10-14, v1, new results, cancer biology, CC BY, University of Utah, abstract) fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0176/","api_url":"https://gliostate.com/api/items/VC0176.json","sameAs":["https://doi.org/10.64898/2026.10.12.758619"],"is_preprint":true,"facets":{"type":"https://gliostate.com/library/type/preprint/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/neuro-oncology/","https://gliostate.com/library/tag/scrna-seq/","https://gliostate.com/library/tag/drug-response/","https://gliostate.com/library/tag/therapy/","https://gliostate.com/library/tag/platform/"]},"cited_by":[],"related":[{"id":"VC0122","title":"SNO 2026 31st Annual Meeting","shared_tags":["neuro-oncology"],"page_url":"https://gliostate.com/library/VC0122/","api_url":"https://gliostate.com/api/items/VC0122.json"},{"id":"VC0171","title":"AI in Neuro-Oncology: An Overarching Review","shared_tags":["neuro-oncology"],"page_url":"https://gliostate.com/library/VC0171/","api_url":"https://gliostate.com/api/items/VC0171.json"},{"id":"VC0123","title":"EANO 2026 (21st meeting)","shared_tags":["neuro-oncology"],"page_url":"https://gliostate.com/library/VC0123/","api_url":"https://gliostate.com/api/items/VC0123.json"},{"id":"VC0183","title":"Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states","shared_tags":["drug-response","therapy"],"page_url":"https://gliostate.com/library/VC0183/","api_url":"https://gliostate.com/api/items/VC0183.json"},{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","shared_tags":["therapy","drug-response"],"page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"},{"id":"VC0140","title":"Divergent genomic evolution in astrocytomas and oligodendrogliomas","shared_tags":["therapy"],"page_url":"https://gliostate.com/library/VC0140/","api_url":"https://gliostate.com/api/items/VC0140.json"}]}