{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"human","system":"human_tissue","evidence_level":"preprint","importance":"","importance_reason":""},"id":"VC0161","type":"preprint","title":"Point-Process Modelling of Cell-Type Interaction Structure in CosMx Glioma Data for Hypothesis-Driven Tumor Inference from scRNA-seq","authors_or_org":"Carcanholo FP, Cassiano MHA, Panepucci EM, Laurini MP, Malta TM.","date":"2026-10-10","year":"2026","venue":"bioRxiv (preprint, not peer-reviewed)","url":"https://doi.org/10.64898/2026.10.02.756019","doi":"10.64898/2026.10.02.756019","pmid":"","brain_tumor_focus":"yes","tags":["GBM","spatial","scRNA-seq","immune"],"tag_slugs":["gbm","spatial","scrna-seq","immune"],"tag_labels":["GBM","Spatial omics","scRNA-seq","Immune"],"tag_labels_zh":["胶质母细胞瘤","空间组学","单细胞 RNA 测序","免疫"],"unmapped_tags":[],"one_line_summary_en":"Preprint (not peer-reviewed): Carcanholo et al. (Ribeirão Preto Medical School, University of São Paulo) fit whole-tissue Log-Gaussian Cox process models to CosMx data from 8 GBM specimens (2,427,362 cells, 15 cell populations, four malignant states); immune populations show spatial attraction toward malignant states; transcript-based features predict cell-level spatial phenotypes, but leave-one-patient-out validation reduced performance and patient-wise harmonisation did not restore cross-patient transportability. Small cohort (8 specimens); the authors state that larger, more diverse spatial cohorts are needed.","one_line_summary_zh":"预印本（未经同行评审）：Carcanholo 等（圣保罗大学里贝朗普雷图医学院）用全组织对数高斯 Cox 过程模型分析 8 例 GBM 样本的 CosMx 数据（2,427,362 个细胞、15 类细胞群、4 种恶性状态）；免疫细胞群在空间上趋近恶性状态细胞；转录特征可预测细胞级空间表型，但留一患者验证使性能下降，按患者校正也未能恢复跨患者可迁移性。样本量小（8 例）；作者指出需要更大、更多样的空间队列。","verified":"yes","verification_source":"bioRxiv API details (title, 5 authors, posted 2026-10-10, v1, new results, CC BY-NC, corresponding institution Ribeirão Preto Medical School - USP, abstract) + Crossref posted-content record fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0161/","api_url":"https://gliostate.com/api/items/VC0161.json","sameAs":["https://doi.org/10.64898/2026.10.02.756019"],"is_preprint":true,"facets":{"type":"https://gliostate.com/library/type/preprint/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/spatial/","https://gliostate.com/library/tag/scrna-seq/","https://gliostate.com/library/tag/immune/"]},"cited_by":[],"related":[{"id":"VC0094","title":"Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.","shared_tags":["gbm","immune","spatial"],"page_url":"https://gliostate.com/library/VC0094/","api_url":"https://gliostate.com/api/items/VC0094.json"},{"id":"VC0162","title":"Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity With High-Density Progenitor Cell Regions Correlating With High-Risk Disease","shared_tags":["spatial","immune"],"page_url":"https://gliostate.com/library/VC0162/","api_url":"https://gliostate.com/api/items/VC0162.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["gbm","immune"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0160","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","shared_tags":["gbm","scrna-seq","spatial"],"page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json"},{"id":"VC0132","title":"Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations","shared_tags":["gbm","scrna-seq"],"page_url":"https://gliostate.com/library/VC0132/","api_url":"https://gliostate.com/api/items/VC0132.json"},{"id":"VC0065","title":"The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.","shared_tags":["spatial","scrna-seq"],"page_url":"https://gliostate.com/library/VC0065/","api_url":"https://gliostate.com/api/items/VC0065.json"}]}