{"scope":{"layer":"brain_tumor","tissue_scope":"brain_tumor","species":"human","system":"human_tissue","evidence_level":"peer_reviewed","importance":"","importance_reason":""},"id":"VC0160","type":"paper","title":"Spatially restricted iron-metabolism-associated stress programs prime invasive mesenchymal glioblastoma states in human tissue-context models","authors_or_org":"Petry C, Boecke AS, Mohammed AO, Ghariwala NS, Jariwala VD, Shhab MA, Buchholz O, Vasilikos I, Nakagawa JM, Vlachos A, Grauvogel J, Shah MJ, Rölz R, Prinz M, Hofmann UG, Beck J, Joseph K, Ravi VM.","date":"2026-10-08","year":"2026","venue":"Neuro-Oncology","url":"https://doi.org/10.1093/neuonc/noag220","doi":"10.1093/neuonc/noag220","pmid":"42844997","brain_tumor_focus":"yes","tags":["GBM","scRNA-seq","spatial","MES-transition","brain-slice"],"tag_slugs":["gbm","scrna-seq","spatial","plasticity","organoid"],"tag_labels":["GBM","scRNA-seq","Spatial omics","Plasticity","Organoid"],"tag_labels_zh":["胶质母细胞瘤","单细胞 RNA 测序","空间组学","细胞可塑性","类器官"],"unmapped_tags":[],"one_line_summary_en":"Petry et al. (University of Freiburg; Neuro-Oncology 2026): multiregional single-nucleus RNA-seq of human GBM tumor core, periphery and infiltrated cortex, validated by spatial transcriptomics, links iron uptake/storage programs to invasion signatures and defines a core-enriched mesenchymal-like, stress-adaptive malignant subpopulation in specific spatial niches. In patient-derived GBM cell lines and human organotypic cortical slice cultures, noncytotoxic iron altered migration in a cell-state-dependent manner and increased growth and invasion (higher VIM, MMP9, HIF1A). The authors note that dependence on these programs was not tested and that the necessity and mechanism of the iron effect remain to be established.","one_line_summary_zh":"Petry 等（弗莱堡大学；Neuro-Oncology 2026）：对人 GBM 肿瘤核心、边缘与浸润皮层做多区域单核 RNA 测序，并以空间转录组验证，发现铁摄取/储存程序与侵袭特征相关，界定出核心富集、位于特定空间生态位的间充质样（MES-like）应激适应恶性亚群。在患者来源 GBM 细胞系与人器官型皮层脑片培养中，非细胞毒剂量的铁以细胞状态依赖方式改变迁移，并增加肿瘤生长与侵袭（VIM、MMP9、HIF1A 上调）。作者指出未检验机制依赖性，铁的必要性与机制尚待确定。","verified":"yes","verification_source":"PubMed E-utilities PMID 42844997 (title, 18 authors, Freiburg affiliations, Neuro Oncol, epub 2026-10-08, accepted 2026-09-03, abstract) + Crossref (journal-article, published online 2026-10-08, article noag220) fetched 2026-10-20; full text not read","page_url":"https://gliostate.com/library/VC0160/","api_url":"https://gliostate.com/api/items/VC0160.json","sameAs":["https://doi.org/10.1093/neuonc/noag220","https://pubmed.ncbi.nlm.nih.gov/42844997/"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/scrna-seq/","https://gliostate.com/library/tag/spatial/","https://gliostate.com/library/tag/plasticity/","https://gliostate.com/library/tag/organoid/"]},"cited_by":[{"id":"cell-state-mes-like","type":"cell_state","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}],"related":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","shared_tags":["gbm","plasticity","scrna-seq"],"page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0093","title":"Spatial epigenomic niches underlie glioblastoma cell state plasticity","shared_tags":["gbm","spatial","plasticity"],"page_url":"https://gliostate.com/library/VC0093/","api_url":"https://gliostate.com/api/items/VC0093.json"},{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","shared_tags":["gbm","plasticity"],"page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["gbm","plasticity"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0156","title":"A perturbation atlas of mouse neural organoids resolves macroglial reactivity and nominates drivers of degeneration","shared_tags":["organoid","scrna-seq"],"page_url":"https://gliostate.com/library/VC0156/","api_url":"https://gliostate.com/api/items/VC0156.json"},{"id":"VC0139","title":"Engineered regulatory states resolve context-dependent genetics in macular degeneration","shared_tags":["plasticity"],"page_url":"https://gliostate.com/library/VC0139/","api_url":"https://gliostate.com/api/items/VC0139.json"}]}