{"id":"VC0139","type":"preprint","title":"Engineered regulatory states resolve context-dependent genetics in macular degeneration","authors_or_org":"Metzner E, Guruvayurappan K, Southard KM, Ardy RC, Dey KK, Norman TM.","date":"2026-10-12","year":"2026","venue":"bioRxiv","url":"https://doi.org/10.64898/2026.10.09.758047","doi":"10.64898/2026.10.09.758047","pmid":"","brain_tumor_focus":"no","tags":["perturbation","Perturb-seq","Multiome","CRISPRa","TF-combinations","chromatin-priming","Mosaic","genetic-interaction","AMD","omnigenic"],"tag_slugs":["perturbation","perturb-seq","multi-omics","plasticity"],"tag_labels":["Perturbation","Perturb-seq","Multi-omics","Plasticity"],"tag_labels_zh":["扰动","Perturb-seq 扰动测序","多组学","细胞可塑性"],"unmapped_tags":["TF-combinations","Mosaic","genetic-interaction","AMD","omnigenic"],"one_line_summary_en":"Norman/Dey labs (MSKCC): CRISPRa Multiome Perturb-seq of 119 TFs + dual-guide Perturb-seq of 1,225 TF pairs in RPE-1; chromatin priming predicts emergent states; Mosaic (Transformer) predicts TF-pair interaction residuals (r=0.484) and nominated a validated triple-TF combination.","one_line_summary_zh":"Norman/Dey 实验室（MSKCC）：在 RPE-1 中对 119 个 TF 做 CRISPRa Multiome Perturb-seq、对 1,225 个 TF 对做双向导 Perturb-seq；染色质预激活可预测新兴状态；Mosaic（Transformer）预测 TF 对相互作用残差（r=0.484），并提名经实验验证的三 TF 组合。","verified":"yes","verification_source":"Crossref;PDF","page_url":"https://gliostate.com/library/VC0139/","api_url":"https://gliostate.com/api/items/VC0139.json","sameAs":["https://doi.org/10.64898/2026.10.09.758047"],"is_preprint":true,"facets":{"type":"https://gliostate.com/library/type/preprint/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/perturbation/","https://gliostate.com/library/tag/perturb-seq/","https://gliostate.com/library/tag/multi-omics/","https://gliostate.com/library/tag/plasticity/"]},"cited_by":[],"related":[{"id":"VC0062","title":"Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.","shared_tags":["multi-omics"],"page_url":"https://gliostate.com/library/VC0062/","api_url":"https://gliostate.com/api/items/VC0062.json"},{"id":"VC0046","title":"Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping","shared_tags":["perturb-seq"],"page_url":"https://gliostate.com/library/VC0046/","api_url":"https://gliostate.com/api/items/VC0046.json"},{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","shared_tags":["plasticity"],"page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"},{"id":"VC0045","title":"X-Atlas/Orion: Genome-wide Perturb-seq Datasets via a Scalable Fix-Cryopreserve Platform for Training Dose-Dependent Biological Foundation Models","shared_tags":["perturb-seq"],"page_url":"https://gliostate.com/library/VC0045/","api_url":"https://gliostate.com/api/items/VC0045.json"},{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["plasticity"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0093","title":"Spatial epigenomic niches underlie glioblastoma cell state plasticity","shared_tags":["plasticity"],"page_url":"https://gliostate.com/library/VC0093/","api_url":"https://gliostate.com/api/items/VC0093.json"}]}