{"id":"VC0129","type":"paper","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","authors_or_org":"Peng et al.","date":"2025-09-17","year":"2025","venue":"preprint","url":"https://doi.org/10.1101/2025.09.12.675826","doi":"10.1101/2025.09.12.675826","pmid":"","brain_tumor_focus":"yes","tags":["GBM","organoid","TMZ","perturbation","AI-agent","drug-response"],"tag_slugs":["gbm","organoid","therapy","perturbation","agents","drug-response"],"tag_labels":["GBM","Organoid","Therapy","Perturbation","AI agents","Drug response"],"tag_labels_zh":["胶质母细胞瘤","类器官","治疗","扰动","AI 智能体","药物反应"],"unmapped_tags":[],"one_line_summary_en":"DELPHAI: AI agent for sc perturbation prediction + LLM mechanism on GBM organoids with TMZ; OT+PCA beat baselines.","one_line_summary_zh":"DELPHAI：GBM类器官+TMZ的单细胞扰动预测与LLM机制解读；最优传输+PCA优于基线。","verified":"yes","verification_source":"Crossref","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json","sameAs":["https://doi.org/10.1101/2025.09.12.675826"],"is_preprint":true,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2025/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/organoid/","https://gliostate.com/library/tag/therapy/","https://gliostate.com/library/tag/perturbation/","https://gliostate.com/library/tag/agents/","https://gliostate.com/library/tag/drug-response/"]},"cited_by":[{"id":"model-virtual-cell","type":"model","title_en":"AI virtual cell models","title_zh":"AI 虚拟细胞模型","url":"https://gliostate.com/models/virtual-cell/","api_url":"https://gliostate.com/api/topics/model-virtual-cell.json"},{"id":"perturbation-gbm-therapy","type":"perturbation","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"},{"id":"transition-therapy-induced-plasticity","type":"transition","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"related":[{"id":"VC0097","title":"Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.","shared_tags":["gbm","organoid","drug-response"],"page_url":"https://gliostate.com/library/VC0097/","api_url":"https://gliostate.com/api/items/VC0097.json"},{"id":"VC0069","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","shared_tags":["gbm","therapy"],"page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"},{"id":"VC0073","title":"Multiscale mathematical model-informed reinforcement learning optimizes combination treatment scheduling in glioblastoma evolution.","shared_tags":["therapy"],"page_url":"https://gliostate.com/library/VC0073/","api_url":"https://gliostate.com/api/items/VC0073.json"},{"id":"VC0135","title":"Harnessing AI to Build Virtual Cells (VCHarness)","shared_tags":["agents","perturbation"],"page_url":"https://gliostate.com/library/VC0135/","api_url":"https://gliostate.com/api/items/VC0135.json"},{"id":"VC0120","title":"AgenticLS @ NeurIPS 2026 — Agentic AI for Biological Discovery","shared_tags":["agents"],"page_url":"https://gliostate.com/library/VC0120/","api_url":"https://gliostate.com/api/items/VC0120.json"},{"id":"VC0044","title":"scBaseCount: An AI agent-curated, standardized, auto-updated single-cell data repository.","shared_tags":["agents"],"page_url":"https://gliostate.com/library/VC0044/","api_url":"https://gliostate.com/api/items/VC0044.json"}]}