{"id":"VC0078","type":"paper","title":"Biological domain shift and statistical nesting concerns in generative AI-based spatial tumor growth prediction for pediatric diffuse midline glioma.","authors_or_org":"Li W, Sun X, Pei S.","date":"2026-08-12","year":"2026","venue":"BMC medicine","url":"https://doi.org/10.1186/s12916-026-05141-y","doi":"10.1186/s12916-026-05141-y","pmid":"42587294","brain_tumor_focus":"yes","tags":["DMG","critique"],"tag_slugs":["dmg","critique"],"tag_labels":["DMG","Critique"],"tag_labels_zh":["弥漫性中线胶质瘤","批评与反证"],"unmapped_tags":[],"one_line_summary_en":"Critique of the DMG generative growth study (domain shift, nesting).","one_line_summary_zh":"对上述DMG生成模型的方法学批评。","verified":"yes","verification_source":"Europe PMC","page_url":"https://gliostate.com/library/VC0078/","api_url":"https://gliostate.com/api/items/VC0078.json","sameAs":["https://doi.org/10.1186/s12916-026-05141-y","https://pubmed.ncbi.nlm.nih.gov/42587294/"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2026/","tags":["https://gliostate.com/library/tag/dmg/","https://gliostate.com/library/tag/critique/"]},"cited_by":[{"id":"validation-benchmarks","type":"validation","title_en":"Validating virtual cells: benchmarks, baselines and critiques","title_zh":"虚拟细胞的验证：基准、基线与批评","url":"https://gliostate.com/validation/benchmarks-and-baselines/","api_url":"https://gliostate.com/api/topics/validation-benchmarks.json"}],"related":[{"id":"VC0077","title":"Generative AI for spatial tumor growth on MRI: a proof-of-principle study in pediatric diffuse midline glioma.","shared_tags":["dmg"],"page_url":"https://gliostate.com/library/VC0077/","api_url":"https://gliostate.com/api/items/VC0077.json"},{"id":"VC0065","title":"The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.","shared_tags":["dmg"],"page_url":"https://gliostate.com/library/VC0065/","api_url":"https://gliostate.com/api/items/VC0065.json"},{"id":"VC0064","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","shared_tags":["dmg"],"page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"},{"id":"VC0056","title":"Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction.","shared_tags":["critique"],"page_url":"https://gliostate.com/library/VC0056/","api_url":"https://gliostate.com/api/items/VC0056.json"},{"id":"VC0048","title":"Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines.","shared_tags":["critique"],"page_url":"https://gliostate.com/library/VC0048/","api_url":"https://gliostate.com/api/items/VC0048.json"},{"id":"VC0049","title":"Benchmarking foundation cell models for post-perturbation RNA-seq prediction.","shared_tags":["critique"],"page_url":"https://gliostate.com/library/VC0049/","api_url":"https://gliostate.com/api/items/VC0049.json"}]}