{"id":"replogle-genome-scale-perturb-seq","type":"dataset","name_en":"Genome-scale Perturb-seq (K562/RPE1)","name_zh":"全基因组规模 Perturb-seq（K562/RPE1）","aliases":["Replogle et al. Perturb-seq"],"description":{"en":"Genome-scale Perturb-seq data (Replogle et al.) in K562 and RPE1 cells; a main training and benchmark resource for current models, from cell lines rather than brain tumor cells.","zh":"K562 与 RPE1 细胞中的全基因组规模 Perturb-seq 数据（Replogle 等）；当前模型的主要训练与基准资源，来自细胞系而非脑肿瘤细胞。"},"externalIds":{},"graphNames":[],"mentions":{"items":["VC0040"],"topics":["perturbation-gbm-therapy"]},"evidenceRefs":["VC0040"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/replogle-genome-scale-perturb-seq/","page_url_zh":"https://gliostate.com/zh/entities/replogle-genome-scale-perturb-seq/","api_url":"https://gliostate.com/api/entities/replogle-genome-scale-perturb-seq.json","external_links":[],"source_file":"https://gliostate.com/data/entities/replogle-genome-scale-perturb-seq.json","evidence_items":[{"id":"VC0040","title":"Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.","year":"2022","page_url":"https://gliostate.com/library/VC0040/","api_url":"https://gliostate.com/api/items/VC0040.json"}],"mentioned_in_items":[{"id":"VC0040","title":"Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.","year":"2022","page_url":"https://gliostate.com/library/VC0040/","api_url":"https://gliostate.com/api/items/VC0040.json"}],"mentioned_in_topics":[{"id":"perturbation-gbm-therapy","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}],"relations":[],"related_entities":[{"id":"perturb-seq","type":"method","name_en":"Perturb-seq","name_zh":"Perturb-seq（扰动单细胞测序）","page_url":"https://gliostate.com/entities/perturb-seq/","page_url_zh":"https://gliostate.com/zh/entities/perturb-seq/","api_url":"https://gliostate.com/api/entities/perturb-seq.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"},{"id":"delphai","type":"model","name_en":"DELPHAI","name_zh":"DELPHAI","page_url":"https://gliostate.com/entities/delphai/","page_url_zh":"https://gliostate.com/zh/entities/delphai/","api_url":"https://gliostate.com/api/entities/delphai.json","via":"co-mention"},{"id":"gbm-organoid","type":"model","name_en":"Patient-derived GBM organoids","name_zh":"患者来源 GBM 类器官","page_url":"https://gliostate.com/entities/gbm-organoid/","page_url_zh":"https://gliostate.com/zh/entities/gbm-organoid/","api_url":"https://gliostate.com/api/entities/gbm-organoid.json","via":"co-mention"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"lincs-l1000","type":"dataset","name_en":"LINCS L1000 drug signatures","name_zh":"LINCS L1000 药物特征谱","page_url":"https://gliostate.com/entities/lincs-l1000/","page_url_zh":"https://gliostate.com/zh/entities/lincs-l1000/","api_url":"https://gliostate.com/api/entities/lincs-l1000.json","via":"co-mention"},{"id":"organoid-drug-screen","type":"method","name_en":"Organoid drug screening","name_zh":"类器官药物筛选","page_url":"https://gliostate.com/entities/organoid-drug-screen/","page_url_zh":"https://gliostate.com/zh/entities/organoid-drug-screen/","api_url":"https://gliostate.com/api/entities/organoid-drug-screen.json","via":"co-mention"},{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","via":"co-mention"}]}