{"id":"h3k27m","type":"gene","name_en":"H3 K27M mutation","name_zh":"H3 K27M 突变","aliases":["H3K27M","H3-K27M"],"description":{"en":"Histone H3 K27M mutation that defines H3K27M gliomas (diffuse midline glioma). Single-cell studies describe developmental and OPC-like programs in these tumors and map their cell states and spatial organisation across age and location.","zh":"定义 H3K27M 胶质瘤（弥漫性中线胶质瘤）的组蛋白 H3 K27M 突变。单细胞研究描述了这些肿瘤的发育与 OPC 样程序，并绘制了其细胞状态与空间组织随年龄和部位的变化。"},"externalIds":{},"graphNames":["H3K27M"],"mentions":{"items":["VC0064","VC0065"],"topics":["cell-state-npc-opc-like"]},"evidenceRefs":["VC0064","VC0065"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/h3k27m/","page_url_zh":"https://gliostate.com/zh/entities/h3k27m/","api_url":"https://gliostate.com/api/entities/h3k27m.json","external_links":[],"source_file":"https://gliostate.com/data/entities/h3k27m.json","evidence_items":[{"id":"VC0064","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","year":"2018","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"},{"id":"VC0065","title":"The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.","year":"2022","page_url":"https://gliostate.com/library/VC0065/","api_url":"https://gliostate.com/api/items/VC0065.json"}],"mentioned_in_items":[{"id":"VC0064","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","year":"2018","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"},{"id":"VC0065","title":"The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.","year":"2022","page_url":"https://gliostate.com/library/VC0065/","api_url":"https://gliostate.com/api/items/VC0065.json"}],"mentioned_in_topics":[{"id":"cell-state-npc-opc-like","title_en":"Neural-progenitor-like (NPC-like) and OPC-like glioma cell states","title_zh":"神经前体样（NPC 样）与少突前体样（OPC 样）胶质瘤细胞状态","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}],"relations":[{"subject":"h3k27m","subject_name_en":"H3 K27M mutation","subject_name_zh":"H3 K27M 突变","predicate":"associated_with","object":"opc-like-state","object_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","object_name_zh":"少突胶质前体细胞样（OPC 样）状态","confidence":"high","evidence":[{"id":"VC0064","role":"supports","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"}],"note":{"en":"OPC-like programs in H3K27M gliomas; the library notes these may not be equivalent to GBM OPC-like states.","zh":"H3K27M 胶质瘤中的 OPC 样程序；文献库提示这些程序未必等同于 GBM 的 OPC 样状态。"},"sources":[{"kind":"topic","id":"cell-state-npc-opc-like","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}]},{"subject":"h3k27m","subject_name_en":"H3 K27M mutation","subject_name_zh":"H3 K27M 突变","predicate":"associated_with","object":"diffuse-midline-glioma","object_name_en":"Diffuse midline glioma, H3 K27-altered (DMG)","object_name_zh":"弥漫性中线胶质瘤，H3 K27 改变型（DMG）","confidence":"high","evidence":[{"id":"VC0064","role":"supports","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"},{"id":"VC0065","role":"supports","title":"The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.","page_url":"https://gliostate.com/library/VC0065/","api_url":"https://gliostate.com/api/items/VC0065.json"}],"note":null,"sources":[{"kind":"topic","id":"cell-state-npc-opc-like","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}]}],"related_entities":[{"id":"opc-like-state","type":"cell_state","name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","name_zh":"少突胶质前体细胞样（OPC 样）状态","page_url":"https://gliostate.com/entities/opc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/opc-like-state/","api_url":"https://gliostate.com/api/entities/opc-like-state.json","via":"relation"},{"id":"diffuse-midline-glioma","type":"disease","name_en":"Diffuse midline glioma, H3 K27-altered (DMG)","name_zh":"弥漫性中线胶质瘤，H3 K27 改变型（DMG）","page_url":"https://gliostate.com/entities/diffuse-midline-glioma/","page_url_zh":"https://gliostate.com/zh/entities/diffuse-midline-glioma/","api_url":"https://gliostate.com/api/entities/diffuse-midline-glioma.json","via":"relation"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"foundation-model","type":"method","name_en":"Single-cell foundation model","name_zh":"单细胞基础模型","page_url":"https://gliostate.com/entities/foundation-model/","page_url_zh":"https://gliostate.com/zh/entities/foundation-model/","api_url":"https://gliostate.com/api/entities/foundation-model.json","via":"co-mention"},{"id":"glial-progenitor-like-state","type":"cell_state","name_en":"Glial-progenitor-like cells","name_zh":"胶质祖细胞样细胞","page_url":"https://gliostate.com/entities/glial-progenitor-like-state/","page_url_zh":"https://gliostate.com/zh/entities/glial-progenitor-like-state/","api_url":"https://gliostate.com/api/entities/glial-progenitor-like-state.json","via":"co-mention"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"idh-mutant-glioma","type":"disease","name_en":"IDH-mutant glioma","name_zh":"IDH 突变型胶质瘤","page_url":"https://gliostate.com/entities/idh-mutant-glioma/","page_url_zh":"https://gliostate.com/zh/entities/idh-mutant-glioma/","api_url":"https://gliostate.com/api/entities/idh-mutant-glioma.json","via":"co-mention"},{"id":"neftel-four-state-framework","type":"method","name_en":"Neftel four-state framework","name_zh":"Neftel 四状态框架","page_url":"https://gliostate.com/entities/neftel-four-state-framework/","page_url_zh":"https://gliostate.com/zh/entities/neftel-four-state-framework/","api_url":"https://gliostate.com/api/entities/neftel-four-state-framework.json","via":"co-mention"}]}