{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","aliases":["AP-1","AP1"],"description":{"en":"In 86 patient-matched primary–recurrent glioblastoma pairs, the shift to a mesenchymal phenotype at recurrence was reported to be mediated by AP-1.","zh":"在 86 对患者配对的原发-复发胶质母细胞瘤中，复发时向间充质表型的转变被报道由 AP-1 介导。"},"externalIds":{},"graphNames":["AP-1"],"mentions":{"items":[],"topics":["cell-state-mes-like","transition-therapy-induced-plasticity"]},"evidenceRefs":["VC0069"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","external_links":[],"source_file":"https://gliostate.com/data/entities/ap-1.json","evidence_items":[{"id":"VC0069","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","year":"2022","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"mentioned_in_items":[],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"transition-therapy-induced-plasticity","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"relations":[{"subject":"ap-1","subject_name_en":"AP-1 transcription factor complex","subject_name_zh":"AP-1 转录因子复合物","predicate":"promotes","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"medium","evidence":[{"id":"VC0069","role":"supports","title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.","page_url":"https://gliostate.com/library/VC0069/","api_url":"https://gliostate.com/api/items/VC0069.json"}],"note":{"en":"Reported as mediating the mesenchymal shift in recurrent tumors; this is an observation at recurrence and does not show whether therapy induces or selects the state.","zh":"报告其介导复发肿瘤的间充质转变；这是复发时的观察，不能区分治疗是诱导还是筛选了该状态。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"co-mention"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","via":"co-mention"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"},{"id":"delphai","type":"model","name_en":"DELPHAI","name_zh":"DELPHAI","page_url":"https://gliostate.com/entities/delphai/","page_url_zh":"https://gliostate.com/zh/entities/delphai/","api_url":"https://gliostate.com/api/entities/delphai.json","via":"co-mention"}]}